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2.2.3. Optimizing Clocking Schemes
Avoid using internally generated clocks (other than PLLs) wherever possible because they can cause functional and timing problems in the design. Clocks generated with combinational logic can introduce glitches that create functional problems, and the delay inherent in combinational logic can lead to timing problems.
Use global device-wide, low-skew dedicated routing for all internally-generated clocks, instead of routing clocks on regular routing lines.
Avoid data transfers between different clocks wherever possible. If you require a data transfer between different clocks, use FIFO circuitry. You can use the clock uncertainty features in the Intel® Quartus® Prime software to compensate for the variable delays between clock domains. Consider setting a clock setup uncertainty and clock hold uncertainty value of 10% to 15% of the clock delay.
The following sections provide specific examples and recommendations for avoiding clocking scheme problems.