Due to problems in the F-Tile Debug Toolkit in the Intel® Quartus® Prime Pro Edition Software v21.4, the F-Tile Debug Toolkit does not run when F-Tile is configured in 1 x4 endpoint mode.
This problem is scheduled to be fixed in a future release of the Intel® Quartus® Prime Pro Edition Software.
A patch is available to fix this problem for the Intel Quartus Prime Pro Edition Software version 21.4. Download and install Patch 0.19 from the following links:
This problem is fixed beginning with the Intel® Quartus® Prime Pro Edition Software version 22.1.