Error(22507): The active serial clock FREQ_100MHZ is not supported in device initialization clock < configuration clock source name >.

Due to a problem in Intel® Quartus® Prime Pro Edition Software version 21.2, this error is issued during compilation when the following two options in the Device and Pin Options are used together. Affected devices: Intel® Arria® 10 device and Intel® Cyclone® 10 GX device.

1. The Configuration clock source in General category is other than Internal Oscillator.
2. The Configuration scheme in Configuration category is other than Active Serial x1 and Active Serial x4.

You can also check the following global assignments in the Quartus Settings File (.qsf).

1. set_global_assignment -name DEVICE_INITIALIZATION_CLOCK <configuration clock source name>
           When <configuration clock source name> is other than INIT_INTOSC
2.  set_global_assignment -name STRATIXV_CONFIGURATION_SCHEME <configuration scheme>
           When <configuration scheme> is other than ACTIVE SERIAL X4 and ACTIVE SERIAL X1
    

To work around this problem, follow these steps:

1. Open the the Quartus Settings File (.qsf) with a text editor
2. Add the following global assignment
   set_global_assignment -name ACTIVE_SERIAL_CLOCK CLKUSR
3. Save and close the the Quartus Settings File (.qsf) 

This problem is fixed starting with the Intel® Quartus® Prime Pro Edition Software version 21.3.