Due to a known problem in Intel® Quartus® Prime Pro Edition software version 20.3 and earlier, ASx4 configuration of Intel® Stratix® 10 devices may fail intermittently when OSC_CLK_1 is used as configuration clock source.
For all Intel® Stratix® 10 devices
AS_CLK is 125MHz
For Intel® Stratix® 10 GX040, Intel® Stratix® 10 SX040, and Intel® Stratix® 10 TX040 devices only,
AS_CLK is 125MHz, or 133MHz
As a workaround, avoid the combinations stated in the description.
This problem is fixed starting with the Intel® Quartus® Prime Pro Edition software version 21.1.