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Bioinformatics is advancing healthcare research by using computation to understand biological data. This computation is useful for large complex datasets that are used to determine gene and protein functions, establish evolutionary relationships, and predict 3D shapes of proteins. Two experts, Sergio Santander-Jimenez at University of Extremadura, and Ricardo Nobre of INESC-ID, are combining the power of modern hardware (CPUs and GPUs), high-performance computing (HPC), and software to advance bioinformatics applications in areas including epistasis detection. Hear how they made it happen.