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As high performance computing (HPC) moves far beyond its traditional users to the domains of AI, machine learning, enterprises, and the cloud, and as heterogeneous programming becomes the norm, Nico Mittenzwey and Mike Lee discuss the considerations in optimizing HPC clusters and applications. Nico explains how the Intel® MPI Library has helped Megware and its customers rise to these challenges, and provides real-world examples of two of the company’s most recent projects. He also explores the challenges of fragmentation in heterogeneous computing environments, and how a single, common programming model can help address these challenges.